Pdf epithelial myoepithelial carcinoma of the parotid gland. We strongly recommend that you talk with a trusted. Case report open access epithelialmyoepithelial carcinoma of the lung. Epithelialmyoepithelial carcinoma emc of salivary gland is a malignant epithelial tumor, composed of two distinct cell types, affecting either the major or. Should not be confused with myoepithelial carcinoma. Myoepithelial carcinoma and epithelialmyoepithelial. Primary salivary glandtype tumors of the lung are rare. Thus, these carcinomas should be widely excised to distinguish them from aggressive malignant tumors like epithelialmyoepithelial carcinoma. Because of its rarity and unproven malignant potential, the optimal therapy for pemc has not been defined. Epithelial cancer definition of epithelial cancer by.
Pathology outlines epithelial myoepithelial carcinoma. Epithelialmyoepithelial carcinoma is regarded as a lowgrademalignancy tumor and the treatment. Case report open access epithelial myoepithelial carcinoma of the lung. Epithelialmyoepithelial carcinoma emc is a lowgrade, malignant biphasic salivary tumor of intercalated duct origin that comprises 12% of all salivary neoplasms. Epithelialmyoepithelial carcinoma of high grade transformation. One week after the onset of the hiccups, he had been seen at an urgent care center. Epithelialmyoepithelial carcinoma of the parotid gland ncbi. Factors shown to affect behavior include positive margins, vascular invasion, necrosis, and myoepithelial anaplasia. The presence of tumor cells outside the myoepithelium distinguishes ductal carcinoma in situ dcis from invasive ductal carcinoma. It is defined as a tumour composed of variable proportions of two cell types which typically form ductlike structures.
Ephitelialmyoepithelial carcinoma, oral cavity, soft palate, immunohistochemistry. Primary epithelialmyoepithelial carcinoma of the lung. Epithelialmyoepithelial carcinoma is a cancer of the parotid salivary duct, with the most common occurrence in elderly people. Four cases of epithelialmyoepithelial carcinoma of the salivary glands arose as painless masses in patients over 60 years old, three in the parotid and one in the submandibular gland. All structured data from the file and property namespaces is available under the creative commons cc0 license. Epithelialmyoepithelial carcinoma of the tongue base. Emec tends to grow in a bulky lobulated fashion,withnecrosisandhyalinizationoflarge tumornodules. Epithelialmyoepithelial carcinoma of the base of tongue. Four cases of epithelialmyoepithelial carcinoma of the salivary glands arose as. Although rare cases of highgrade emca have been reported, 3,58. A few cases of epithelialmyoepithelial carcinoma arising in the nasal cavity have been reported. Epithelialmyoepithelial carcinoma is an rare tumour occurring in the salivary glands, most commonly in the parotid gland, with a reported incidence of between 0.
Radiation therapy can be used to reduce the chance that the tumor could return in the same location. Epithelialmyoepithelial carcinoma lester dr thompson, md. Epithelialmyoepithelial carcinoma emc is a rare glandular epithelial neoplasm of the salivary gland, with an incidence of less than 1 percent of all salivary gland tumors. It is usually seen in older age groups 5060 years and is rare in children. They are predominantly found in the parotid gland and represent approximately 1%. Use of immunohistochemical stains in epithelial lesions of the breast laila khazai, md, and marilin rosa, md. Pulmonary epithelial myoepithelial carcinoma pemc is a rare subset of salivary glandtype tumors. Epithelialmyoepithelial carcinoma emca is a rare malignant tumour that typically arises in a salivary gland and consists of both an epithelial and myoepithelial component. Though the name for this tumor was coined by donath et al.
Epithelialmyoepithelial carcinoma, abbreviated emca, is a rare malignant salivary gland tumour. There is limited evidence about the usefulness of chemotherapy in treating myoepithelial carcinoma, and there are no standard treatment guidelines. Ovarian carcinoma is traditionally referred to as a single entity, but it consists of a heterogeneous group of neoplasms with multiple histologic subtypes. Epithelialmyoepithelial carcinoma of the parotid gland. Induction of twist1 led to dissemination of both luminal epithelial and myoepithelial cells, consistent with our previous study. Infiltrating myoepithelial carcinoma of the breast, a case. Breast adenomyoepithelioma is an unusual tumor characterized by a biphasic proliferation of epithelial and myoepithelial cells. The salivary epithelialmyoepithelial carcinoma of intercalated duct origin is a distinctive, biologically lowgrade carcinoma with a predilection for the parotid gland. However, epithelialmyoepithelial carcinoma with highgrade transformation emc with hgt is extremely rare, therefore it is easily to be inappropriately diagnosed and treated.
Epithelialmyoepithelial carcinoma emc is a rare salivary gland tumor of presumed intercalated duct origin with a low risk of metastasis and mortality. Unusual epithelialmyoepithelial carcinoma in palate case. Approximately 66% of these tumors occur in a part of the salivary gland, known as the parotid gland. Epithelialmyoepithelial carcinoma of parotid glanda. Fine needle aspiration cytology is widely used in the initial investigation of salivary gland swellings and whilst the cytological features of this tumour have been described they are not well recognized.
The presence or absence of a myoepithelial cell layer around carcinoma cells is the basis for divid ing tumors into in situ and invasive types. An epithelial myoepithelial carcinoma in parotid gland. Epithelial myoepithelial carcinoma emc is a rare malignant salivary gland neoplasm that most commonly occurs in the parotid gland, but can also arise in. In this study, we aim to examine the demographic, clinicopathologic, and survival features of emc using a populationbased approach. Epithelialmyoepithelial carcinoma of external auditory.
Epithelialmyoepithelial carcinoma emca is an uncom mon, biphasic salivary gland malignancy composed of ductal epithelial cells and myoepithelial cells. It is also known as a malignant myoepithelial tumor. In its classic form, this carcinoma demonsrates a nodular growth pattern composed of well. Emc generally occurs in the parotid gland, but some cases in the maxillary sinus, nasal cavity, trachea, larynx and lacrimal gland have been reported. Pulmonary epithelialmyoepithelial carcinoma pemc is a rare subset of salivary glandtype tumors. Most breast adenomyoepitheliomas are considered to be benign or to have a lowgrade malignant potential, characterized by propensity for local recurrence. Epithelialmyoepithelial carcinoma of lung is a very rare type of lung carcinomas of the salivary gland type pathology. Introduction epithelialmyoepithelial carcinoma emc is defined by the world health organization who classification in 1991 as a rare lowgrade malignant neoplasm and. Donath and coworkers are usually accredited with calling attention to. Pdf epithelialmyoepithelial carcinoma emc is a lowgrade malignant tumor of the salivary glands. Epithelialmyoepithelial carcinoma of parotid gland a. It comprises approximately 1 to 2% of salivary gland.
Rare, low grade tumor with epithelial and myoepithelial components and frequent local recurrence also called glycogen rich adenoma clear cell pattern, myoepithelioma spindle cell and plasmacytoid patterns, myoepithelial carcinoma if only myoepithelial differentiation and marked cytologic atypia. Epithelialmyoepithelial carcinoma emc is a rare biphasic tumor of the salivary gland. Full text get a printable copy pdf file of the complete article 280k, or click on a page image below to browse page by page. Myoepithelial cells in these cases constitute the basal cell layer of an epithelium that harbors the epithelial progenitor. Epithelial myoepithelial carcinoma emc is a rare neoplasm of the salivary glands. Epithelial carcinoma is the most common histologic type of cancer of the ovary, fallopian tube, and peritoneum, accounting for 90 percent of all cancers at these sites. Malignant changes arising in this lesion are extremely rare and may. Epithelialmyoepithelial carcinoma is a relatively uncommon malignant neoplasm. Presence of myoepithelial cells in a hyperplastic tissue proves the benignity of the gland and, when absent, indicates cancer. Infiltrating myoepithelial carcinoma remains a rarely encountered lesion of the breast. Epithelialmyoepithelial carcinoma of salivary gland.
Diagnosis is based on the identification of myoepithelial cells, with spindle cells, clear cells, or plasmacytoid differentiation or a mixture of phenotypes, along with a variable abundance of ductforming epithelium. Emc accounts for about 1% of salivary gland tumors. Get a printable copy pdf file of the complete article 1. Linkpage citation a 49yearold, hivpositive man with a cd4 count of 81 cellsmicrol presented with a 3week history of hiccupping. See the article myoepithelial carcinoma malignant myoepithelioma of the parotid gland arising in a pleomorphic adenoma. Epithelialmyoepithelial carcinoma arising from the.
In this case report, we describe, to our best of knowledge, the wrst case of a patient with a synchronous bilateral epithelialmyoepithelial carcinoma of the parotid gland. Media in category carcinomas the following 20 files are in this category, out of 20 total. Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrixproducing and spindle cell carcinomas nikolay k. The relatively recently recognized and rarely encountered malignant myoepithelial tumor ie, myoepithelial carcinoma was first described by stromeyer et al 11 in 1975 and has been included in the world health organization classification of salivary gland tumors since 1991. Histologically, all the tumours were composed of small ducts with a double cell lining surrounded by a basement membrane. Other localized forms of epithelial carcinoma include acinar adenocarcinoma, which affects the prostate. The few cases that have surfaced firmly document the histopathology of this tumor, but its cytologic characteristics seemingly have been described in only one other report. Epithelial myoepithelial carcinoma emca is a salivary tumor with dual cell population.
Epithelial myoepithelial carcinoma is an uncommon neoplasm comprising 1% of all salivary gland tumours. Use of immunohistochemical stains in epithelial lesions of. Epithelialmyoepithelial carcinoma emc is a rare type of malignant tumor, accounting for about 1% of all salivary gland tumors 1,2 and recognizes a typical biphasic pattern. Introduction epithelialmyoepithelial carcinoma emc is defined by the world health organization who classification in 1991 as a rare lowgrade maligvary glands tumors 1,2. We describe a unique case of aggressive epithelialmyoepithelial carcinoma in the nasal cavity. Frequent morphologic and molecular evidence of preexisting pleomorphic. Epithelialmyoepithelial carcinoma is a rare neoplasm that usually arises from the salivary glands, comprising approximately 1% of all salivary gland tumours 1, 2. Epithelialmyoepithelial carcinoma emc is a rare biphasic tumor of the salivary glands typically arising in the parotid. Myoepithelial carcinoma is an uncommon, malignant, soft tissue tumor of myoepithelial cells. Primary epithelialmyoepithelial carcinoma of the lacrimal.
Epithelialmyoepithelial carcinoma is an uncommon, lowgrade carcinoma that generally occurs in the salivary glands. New variants of epithelialmyoepithelial carcinoma archives of. Pulmonary epithelialmyoepithelial carcinoma pemc is a rare subset of salivary glandtype tumors of the lung. Typical microscopic findings involve the dual composition of an inner eosinophilic ductal cell layer and an outer clear myoepithelial cell layer. The treatment for metastatic myoepithelial carcinoma usually begins with surgery to remove the main tumor. Myoepithelial cell differentiation markers in ductal. Epithelialmyoepithelial carcinoma emc, on the other hand, is a tumour with biphasic histology. It is a hybrid tumour, composed of two different tumour entities, each of which conforms to a defined tumour category 4, 5 and based upon the salivary gland. Epithelialmyoepithelial carcinoma of lung radiology. Epithelial myoepithelial carcinoma emc is a rare biphasic tumor of salivary glands with low malignant potential. Myoepithelial carcinoma is a rare malignant cancerous tumor that usually occurs in the salivary glands in the mouth, but can also occur in skin and soft tissues. Epithelialmyoepithelial carcinoma emc is a rare type of malignant tumor of salivary gland accounting for less than 1.
Pdf epithelialmyoepithelial carcinoma of the parotid gland. Thetumorhasadistinctivehistopathologic pattern with a proliferation of. Myoepithelial cells are a dynamic barrier to epithelial. Epithelialmyoepithelial carcinoma in the base of the. Here we present the cytologic findings from a case of infiltrating myoepithelial carcinoma of the breast. Synchronous bilateral epithelialmyoepithelial carcinoma. Epithelialmyoepithelial carcinoma emca is a salivary tumor with dual cell population. It is generally composed of variable proportions of two cell types. It is similar to salivary gland myoepithelial tumors showing same histological features morphology. Epithelial myoepithelial carcinoma is histologically most significant for its biphasic cellular profile 1,5.
Epithelialmyoepithelial carcinoma of salivary glands. In the case of wound healing, myoepithelial cells reactively proliferate. Epithelialmyoepithelial carcinoma emc is regarded as a rare lowgrade malignant tumor of the salivary gland, accounting for 0. Epithelial myoepithelial carcinoma of parotid gland. Pleuromediastinal epithelialmyoepithelial carcinomas.
Epithelialmyoepithelial carcinoma genetic and rare. The histologic appearance of epithelial myoepithelial carcinoma varies not only from carcinoma to carcinoma but also within the same neoplasm. Since it was first described in 1972, there have only been 566 cases of epithelialmyoepithelial carcinoma described in. Epithelialmyoepithelial carcinoma emc is a rare and lowgrade malignant neoplasm that was first described by donath et al in 1972. Epithelialmyoepithelial carcinoma emc is a malignant neoplasm demonstrating a characteristic biphasic pattern of inner ductal cells and an outer layer of myoepithelial cells. Epithelialmyoepithelial carcinoma of the salivary glands. Objective of this study is to highlight the importance of considering clinical and radiological findings in parotid tumors before operating tumors with high suspicion of malignancy though reported as benign on histopathology.
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